Drilled and slotted hasn't effected my pad life noticeably. It does shorten pad life, but not material to me.
Drilled and slotted is for looks.
Rarely will you see track cars, if any, with slots or drilled. Porsche is one of the few that casts the holes (not drilling) but swaps to plain rotors when they professionally track.
More surface area = more friction.
If you go into cast carbon rotors, that's a whole different level.
Street, I think slotted is the way to go unless you get cross drilled from someone reputable.
Slotted and cross drilled has advantages such as helping removing glaze on pads, "sweeping" them on each revolution, better cooling of rotors, areas for built up gases to escape, etc.
Disadvantages as well such as faster pad wear, cross drilled can be prone to cracking, less surface area, etc.
Aesthetically, I am a huge fan of cross drilled and slotted.
Unless you autocross or track, I doubt anyone will reach the fade limit on OEM.
Jonas, I'd go cytogenetic treated centric rotors, slotted if I were you.
I'd even go as far to say bbk and sell your akebono's
