This certainly isnt scientific by any means, but I drove our 2017 QX50 from Huntsville, AL to the Orlando, Fl area a couple of weeks ago. We used premium (93) all the way down and because fuel prices at the time in FL were wayyyyy higher there than here (right after the monsoons that flooded South Florida making fuel distribution in the state a problem), we ran regular (87) all the way back and the on-board fuel monitor showed almost identical numbers... 26.8 on the way down and 26.7 on the return at 80 mph on the interstates. And yes, I did reset the computer prior to return. Didnt really notice any performance difference either. Don't know what kind of issues may develop over the long term, though.